Suspicious Choroidal Lesions: Identifying Melanoma

Apr 26, 2022
9 min read

Uveal melanoma is the most common tumor originating inside the eye.1,2 Uveal melanoma may affect any three parts of the uveal tract (i.e., the iris, ciliary body, or choroid); however, it most commonly affects the choroid.1,2

As there are only six cases per million, there is limited widespread knowledge regarding the exact etiology of this disease. The early presentation can be nonspecific, and lesions may even be found on routine screening. Thus knowledge regarding risk factors, high-risk characteristics of lesions, and appropriate workup are critical to preventing the growth and spread of the primary tumor and metastasis.

Risk factors for choroidal melanoma

Age, ethnicity, and iris color are risk factors for developing choroidal melanoma. Fairer-skinned individuals with light-colored irises are more susceptible to choroidal melanoma.3

Although risk increases with age, choroidal melanoma may also occur in children. When occurring in children, the rate of iris melanoma is much higher than other uveal melanomas.

Genetic markers also indicate risk factors, prognosis, and risk of metastasis. Proto-oncogenes, like MAPK and GNAQ activation, are associated with 50% of cases of uveal melanoma, and the incidence of the HLA-B40 haplotype is implicated in uveal melanoma metastasis. The incidence of choroidal melanoma has been further investigated with BAP1 somatic gene mutations and continues to be explored due to its potential as a genetic screening tool for hereditary melanoma.4,5

Symptoms of choroidal melanoma

Symptoms may or may not be present in individuals with early disease. Symptoms that sometimes occur with choroidal melanoma include eye pain, floaters, decreased or blurred vision, and visual field loss.2

Figure 1 illustrates primary choroidal melanoma.6

Primary Choroidal Melanoma.png

Figure 1: Courtesy of Harris Ahmed, DO, MPH

Early diagnosis of choroidal melanoma can prevent metastasis. Metastasis occurs in 16% of patients with melanomas less than 4 mm thick, 32% of patients with 4-8 mm thick melanomas and 53% of patients with more than 8 mm thick melanomas.7 Prognosis depends largely on the grading and staging of the melanoma and whether or not there is metastasis.

Identifying choroidal melanoma

Often, lesions may be discovered on routine screening or follow-up for unrelated eye problems. In these scenarios, it is essential to risk stratify the lesions based on specific criteria. Studies by Shields et al. at the Ocular Oncology Service at Wills Eye Hospital have established such criteria.

Risk factors for choroidal lesions that are suspicious for melanoma include thickness greater than 2 mm, orange color pigment, subretinal fluid, the presence of symptoms, and the margin of the lesion is 3 mm or less from the disc. Additional risk factors include acoustic hollowness, surrounding halo, and absence of drusen.

Figure 2 demonstrates high-risk choroidal melanoma, classified by MOLES criteria.6

high-risk choroidal melanoma

Figure 2: Courtesy of Harris Ahmed, DO, MPH

Shields et al. showed that lesion thickness is both a risk factor and an indicator of metastasis. The thickness of the lesion by one-millimeter increments in melanoma can increase the risk for metastatic disease by 5%. If two risk factors are present, then the chance of tumor growth can be 45-50% compared to 36-38% with one risk factor (TABLE 1).7,8

Progression of high risk or diffuse choroidal melanoma can also be evaluated with MOLES criteria:

  • Mushroom shape
  • Orange pigment
  • Large size
  • Enlarging
  • Subretinal fluid

Increase in risk factors increases the relative risk and tumor growth7,8

Risk Factors Relative Risk for Tumor Growth Percentage of patients (1287) with small choroidal melanocytic tumors
None 0 4%
Tumor thickness greater than 2 mm 1.9 36-38%
Tumor thickness greater than 2 mm, posterior tumor margin touching the disc 3.8 45-50%
Tumor thickness greater than 2 mm, posterior tumor margin touching the disc, visual symptoms 7.4 50%
Tumor thickness greater than 2 mm, posterior tumor margin touching the disc, visual symptoms, orange pigment 14.1 51%
Tumor thickness greater than 2 mm, Posterior tumor margin touching the disc, visual symptoms, orange pigment, subretinal fluid 27.1 56%

Screening for choroidal melanoma

Screening for choroidal melanoma with a dilated fundus exam is a recommended mainstay of preventive care for patients. Even before symptoms are present, routine comprehensive eye exams are responsible for recognizing one-third of choroidal melanoma cases. One dilemma with uveal melanoma is that choroidal lesions that progress to melanoma can sometimes be confused for benign nevi.

Figure 3 represents benign choroidal nevus.

Benign choroidal nevus.jpg

Figure 3

Suspicious pre-cancerous lesions in the choroid can sometimes be distinguished from choroidal nevi by lesion thickness greater than 2 mm, as mentioned by B-scan ultrasound. Choroidal lesions that do not have those risk factors for melanoma discussed above are most likely choroidal nevi. The potential for progression to choroidal melanoma occurs in 1 in 8,000 cases of choroidal nevi. It should be monitored with imaging modalities such as B scan ultrasound, optical coherence tomography (OCT), and widefield fundus photography.

Managing choroidal melanoma

If a choroidal lesion is confirmed melanoma, disease management may include radiation (plaque or proton beam radiation) or enucleation when end-stage disease. Plaque radiotherapy is the standard treatment available for choroidal melanoma, which involves high dose radiation to the lesion. It is most successful for small to medium choroidal lesions with a 3% recurrence rate in 97% of patients at five years,9 and visual acuity was preserved in 50% of patients at 20/50 at ten-year follow-up.10

Due to the radiation injury risk from plaque radiotherapy in thicker and larger choroidal lesions. An investigational treatment drug called light-activated AU-0,10 developed by Aura Biosciences is in phase 1 clinical trial. It uses viral nanoparticle conjugates alongside an ophthalmic laser treatment for eliminating cancer cells in ocular melanoma patients.11

Figure 4 illustrates malignant choroidal melanoma.12