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Suspicious Choroidal Lesions: Identifying Melanoma

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To decrease the risk of growth and potential metastasis, diagnosis between benign choroidal nevi and melanoma should be established early. Learn about the risk factors, identification, screening, and treatment.
Suspicious Choroidal Lesions: Identifying Melanoma
Uveal melanoma is the most common tumor originating inside the eye.1,2 Uveal melanoma may affect any three parts of the uveal tract (i.e., the iris, ciliary body, or choroid); however, it most commonly affects the choroid.1,2
As there are only six cases per million, there is limited widespread knowledge regarding the exact etiology of this disease. The early presentation can be nonspecific, and lesions may even be found on routine screening. Thus knowledge regarding risk factors, high-risk characteristics of lesions, and appropriate workup are critical to preventing the growth and spread of the primary tumor and metastasis.

Risk factors for choroidal melanoma

Age, ethnicity, and iris color are risk factors for developing choroidal melanoma. Fairer-skinned individuals with light-colored irises are more susceptible to choroidal melanoma.3
Although risk increases with age, choroidal melanoma may also occur in children. When occurring in children, the rate of iris melanoma is much higher than other uveal melanomas.
Genetic markers also indicate risk factors, prognosis, and risk of metastasis. Proto-oncogenes, like MAPK and GNAQ activation, are associated with 50% of cases of uveal melanoma, and the incidence of the HLA-B40 haplotype is implicated in uveal melanoma metastasis. The incidence of choroidal melanoma has been further investigated with BAP1 somatic gene mutations and continues to be explored due to its potential as a genetic screening tool for hereditary melanoma.4,5

Symptoms of choroidal melanoma

Symptoms may or may not be present in individuals with early disease. Symptoms that sometimes occur with choroidal melanoma include eye pain, floaters, decreased or blurred vision, and visual field loss.2
Figure 1 illustrates primary choroidal melanoma.6
https://covalentcareers3.s3.amazonaws.com/media/original_images/Primary_Choroidal_Melanoma_yUlVLMz.png
Figure 1: Courtesy of Harris Ahmed, DO, MPH
Early diagnosis of choroidal melanoma can prevent metastasis. Metastasis occurs in 16% of patients with melanomas less than 4 mm thick, 32% of patients with 4-8 mm thick melanomas and 53% of patients with more than 8 mm thick melanomas.7 Prognosis depends largely on the grading and staging of the melanoma and whether or not there is metastasis.

Identifying choroidal melanoma

Often, lesions may be discovered on routine screening or follow-up for unrelated eye problems. In these scenarios, it is essential to risk stratify the lesions based on specific criteria. Studies by Shields et al. at the Ocular Oncology Service at Wills Eye Hospital have established such criteria.
Risk factors for choroidal lesions that are suspicious for melanoma include thickness greater than 2 mm, orange color pigment, subretinal fluid, the presence of symptoms, and the margin of the lesion is 3 mm or less from the disc. Additional risk factors include acoustic hollowness, surrounding halo, and absence of drusen.
Figure 2 demonstrates high-risk choroidal melanoma, classified by MOLES criteria.6
https://covalentcareers3.s3.amazonaws.com/media/original_images/high-risk_choroidal_melanoma.png
Figure 2: Courtesy of Harris Ahmed, DO, MPH
Shields et al. showed that lesion thickness is both a risk factor and an indicator of metastasis. The thickness of the lesion by one-millimeter increments in melanoma can increase the risk for metastatic disease by 5%. If two risk factors are present, then the chance of tumor growth can be 45-50% compared to 36-38% with one risk factor (TABLE 1).7,8
Progression of high risk or diffuse choroidal melanoma can also be evaluated with MOLES criteria:
  • Mushroom shape
  • Orange pigment
  • Large size
  • Enlarging
  • Subretinal fluid

Increase in risk factors increases the relative risk and tumor growth7,8

Risk FactorsRelative Risk for Tumor GrowthPercentage of patients (1287) with small choroidal melanocytic tumors
None04%
Tumor thickness greater than 2 mm1.936-38%
Tumor thickness greater than 2 mm, posterior tumor margin touching the disc3.845-50%
Tumor thickness greater than 2 mm, posterior tumor margin touching the disc, visual symptoms7.450%
Tumor thickness greater than 2 mm, posterior tumor margin touching the disc, visual symptoms, orange pigment14.151%
Tumor thickness greater than 2 mm, Posterior tumor margin touching the disc, visual symptoms, orange pigment, subretinal fluid27.156%

Screening for choroidal melanoma

Screening for choroidal melanoma with a dilated fundus exam is a recommended mainstay of preventive care for patients. Even before symptoms are present, routine comprehensive eye exams are responsible for recognizing one-third of choroidal melanoma cases. One dilemma with uveal melanoma is that choroidal lesions that progress to melanoma can sometimes be confused for benign nevi.
Figure 3 represents benign choroidal nevus.
https://covalentcareers3.s3.amazonaws.com/media/original_images/Benign_choroidal_nevus.jpg
Figure 3
Suspicious pre-cancerous lesions in the choroid can sometimes be distinguished from choroidal nevi by lesion thickness greater than 2 mm, as mentioned by B-scan ultrasound. Choroidal lesions that do not have those risk factors for melanoma discussed above are most likely choroidal nevi. The potential for progression to choroidal melanoma occurs in 1 in 8,000 cases of choroidal nevi. It should be monitored with imaging modalities such as B scan ultrasound, optical coherence tomography (OCT), and widefield fundus photography.

Managing choroidal melanoma

If a choroidal lesion is confirmed melanoma, disease management may include radiation (plaque or proton beam radiation) or enucleation when end-stage disease. Plaque radiotherapy is the standard treatment available for choroidal melanoma, which involves high dose radiation to the lesion. It is most successful for small to medium choroidal lesions with a 3% recurrence rate in 97% of patients at five years,9 and visual acuity was preserved in 50% of patients at 20/50 at ten-year follow-up.10
Due to the radiation injury risk from plaque radiotherapy in thicker and larger choroidal lesions. An investigational treatment drug called light-activated AU-0,10 developed by Aura Biosciences is in phase 1 clinical trial. It uses viral nanoparticle conjugates alongside an ophthalmic laser treatment for eliminating cancer cells in ocular melanoma patients.11
Figure 4 illustrates malignant choroidal melanoma.12
https://covalentcareers3.s3.amazonaws.com/media/original_images/Malignant_choroidal_melanoma.jpg
Figure 4
Genetics play a role in presenting choroidal melanoma; subsequently, anti-PD-1 monoclonal antibodies such as pembrolizumab against MAPK and GNAQ have been explored, but with little benefit in minority populations. The continuation of yearly dilated exams as well as management of any arising complications should be followed for health maintenance.
Choroidal melanoma sequelae include macular edema, retinal detachment, neovascularization, and recurrence and are managed in follow-up after appropriate diagnosis and treatment.

Conclusions and differential diagnosis for choroidal melanoma

Although preventative measures like screening and treatment modalities are available, choroidal melanoma continues to have a high mortality rate of 62% with metastasis and 9% without metastasis.13 Disease related mortality also showed that patients with one site or more of metastasis showed 54% survival at the 7.4 year mark.13
Differential diagnosis between benign choroidal nevi and melanoma should be established early and risk factors evaluated to decrease the risk of growth and potential metastasis. Genetic targets, multimodal therapies, and investigational drugs continue to be a new source of possible treatments and disease management.

References

  1. Van, Poppelen NM,, et al. “Genetics of Ocular Melanoma: Insights into Genetics, Inheritance and Testing.” Int. J. Mol. Sci., no. 22, 2021, p. 336.
  2. B Quinn, Nicola, et al. “Prevalence and characteristics of peripheral retinal lesions in an aging population.” Invest. Ophthalmol. Vis. Sci, vol. 15, no. 8, 2017, p. 1497.
  3. Moss, Cathy. “New Clinical Trial for Early-Stage Eye Melanoma.” Wills Eye Hospital, 24 April 2017, https://www.willseye.org/new-clinical-trial-early-stage-eye-melanoma/. Accessed 10 April 2022.
  4. Luo H,, Ma C. “Identification of prognostic genes in uveal melanoma microenvironment.” PLOS ONE, vol. 20, no. 11, 2020.
  5. Helgadottir H, Höiom V. “The genetics of uveal melanoma: current insights.” Appl Clin Genet, vol. 9, 2016, pp. 147-155.
  6. Ahmed, Harris, et al. “Differential Diagnosis for a Pigmented Fundus Lesion with Downloadable Cheat Sheet.” Eyes On Eyecare, 26 January 2022, https://eyesoneyecare.com/resources/differential-diagnosis-for-a-pigmented-fundus-lesion-with-downloadable-cheat-sheet/. Accessed 10 April 2022.
  7. Shields, Carol L., and Hakan Demirci. “Clinical factors in the identification of small choroidal melanoma.” PubMed, June 2004, https://pubmed.ncbi.nlm.nih.gov/15327099/. Accessed 10 April 2022.
  8. Shields, Carol L., et al. “Combination of clinical factors predictive of growth of small choroidal melanocytic tumors.” Arch Ophthalmol ., vol. 118, no. 3, 2000, pp. 360-364.
  9. Shields CL, Cater J, Shields JA, et al. Combined plaque radiotherapy and transpupillary thermotherapy for choroidal melanoma: tumor control and treatment complications in 270 consecutive patients. Arch Ophthalmol 2002;120:933–940.
  10. Say, E. T., et al. “Plaque Radiotherapy for Management of Small Choroidal Melanoma: A Series of 1251 Cases.” Investigative Ophthalmology and Visual Sciences, vol. Volume 51, no. Issue 13, 2010.
  11. Moss, Cathy. “New Clinical Trial for Early-Stage Eye Melanoma.” Wills Eye Hospital, 24 April 2017, https://www.willseye.org/new-clinical-trial-early-stage-eye-melanoma/. Accessed 10 April 2022.
  12. Ko, Paula. “Ocular Tumors: Choroidal Nevus Vs. Choroidal Melanoma.” The Women's Journal, 1 October 2017, https://thewomensjournal.com/ocular-tumors-choroidal-nevus-vs-choroidal-melanoma/. Accessed 10 April 2022.
  13. The Collaborative Ocular Melanoma Study Group. Assessment of Metastatic Disease Status at Death in 435 Patients With Large Choroidal Melanoma in the Collaborative Ocular Melanoma Study (COMS): COMS Report No. 15. Arch Ophthalmol. 2001;119(5):670–676. doi:10.1001/archopht.119.5.670.
Zurriat Syed, MS
About Zurriat Syed, MS

Zurriat Syed is a medical student at Lincoln Memorial University DeBusk College of Osteopathic Medicine. She is a graduate of University of California, Berkeley with a bachelor’s degree in molecular cell biology and a master’s in science.

Zurriat Syed, MS
Harris Ahmed DO, MPH
About Harris Ahmed DO, MPH

Harris Ahmed DO, MPH is a resident physician in ophthalmology at the Loma Linda University Eye Institute. He is a leader in health policy, serving in national leadership positions in multiple organizations including the AMA, AOCOOHNS, and AOA and has authored many publications and given lectures on public health advocacy and health policy, specializing in topics such as scope of practice, physician distribution, and medical education.

Harris Ahmed DO, MPH
David RP Almeida, MD, MBA, PhD
About David RP Almeida, MD, MBA, PhD

David Almeida MD MBA PhD is a vitreoretinal eye surgeon offering a unique voice that combines a passion for ophthalmology, vision for business innovation, and expertise in ophthalmic and biomedical research. He is part of Erie Retinal Surgery, a retina-only private practice with an esteemed reputation for excellence in Pennsylvania. Dr. Almeida and Erie Retinal Surgery diagnose and treat all medical and surgical conditions of the vitreous, retina and macula.

David RP Almeida, MD, MBA, PhD
Eric K Chin, MD
About Eric K Chin, MD

Dr. Eric K Chin is a board-certified ophthalmologist in the Inland Empire of Southern California. He is a partner at Retina Consultants of Southern California, and an Assistant Professor at Loma Linda University and the Veterans Affair (VA) Hospital of Loma Linda. He is a graduate of University of California Berkeley with a bachelor’s of science degree in Bioengineering. Dr. Chin received his medical degree from the Chicago Medical School, completed his ophthalmology residency at the University of California Davis, and his surgical vitreoretinal fellowship at the University of Iowa. During his residency and fellowship, he was awarded several accolades for his teaching and research in imaging and novel treatments for various retinal diseases.

Eric K Chin, MD
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