Published in Cornea

How to Treat Corneal Scarring: A Resident's Guide

This is editorially independent content
7 min read
Refine your understanding of corneal scarring with this step-by-step guide to identifying, diagnosing, and treating this ocular condition.
How to Treat Corneal Scarring: A Resident's Guide
The cornea is a very unique part of our eyes. A key histological feature of the cornea is the specific pattern of collagen within the stroma and its avascularity, which give the cornea its unique transparency and the capacity to focus light on the retina.
Changes to collagen that can lead to “corneal leukoma” or corneal scarring:1
  • Type
  • Size
  • Distribution
  • Inflammation
  • Spatial organization due to infection
  • Any other cause of opacity and irregularities
The cornea covers the pupil, iris, and anterior chamber. If a scar is peripheral, or even paracentral, it may not alter the vision at all. However, if the scar is centrally located it may cause a significant loss of vision.
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Layers of the Cornea

1) Epithelium

  • Barrier to microbes, chemicals, and water

2) Bowman’s layer

  • Maintains corneal shape

3) Stroma

  • Mechanical Strength
  • Transparency

4) Descemet’s membrane

  • Basement membrane anterior to endothelial cells

5) Endothelium

  • Responsible for the transparency of the cornea by regulating the stromal water content (“water pumps”)2

Causes of corneal scarring

  • Severe dry eye
  • Injury or trauma (idiopathic, chemical, and surgical)
  • Infections
  • Diseases of the cornea or eye surfaces, such as keratoconus

Symptoms of corneal scarring

The typical symptoms of corneal scarring are blurred vision, light sensitivity, pain, and foreign body sensation. Corneal scarring often presents as a complication of another condition; therefore, it usually presents as a change in the signs and symptoms of these preexisting conditions, mainly a change in the visual acuity.
For example: keratoconus is usually a bilateral disease, however if there are complications caused by corneal scarring, patients may present with asymmetric symptoms such as one eye may be much more severely blurred than the other.4

Diagnosis of corneal scarring

The vast majority of corneal scars and their underlying causes can be easily diagnosed during a routine slit lamp exam. Corneal scarring has a characteristic white opacity and an associated loss of the normal clarity of the cornea. Sometimes, corneal scars are easy to detect with just a pocket flashlight.
Anterior scars may or may not alter corneal topography; they may also simply create a haze, leading to reduced visual acuity. Corneal topography and anterior segment OCT can help delineate the extent of scarring and also aid in surgical planning.

Treatment options

Patients with severe vision loss due to central corneal scars can benefit from visual rehabilitation. For mild scars, the refractive error from the scar may be corrected with glasses or contact lenses (soft, scleral, and rigid gas permeable lenses are options).
In some cases of anterior scars, mainly involving the Bowman’s layer and the anterior stroma, a superficial keratectomy (SK) may be performed.4 Here, a lamellar resection of the diseased cornea is removed manually and a bandage contact lens is placed to allow for healing.
In some severe cases of corneal scarring, neither glasses nor contact lenses can improve vision. In these situations, a corneal transplant can be considered.
Over the last few decades corneal transplantation techniques have rapidly expanded from the traditional full thickness penetrating keratoplasty (PKP) towards selective lamellar keratoplasty to only remove the diseased layers of the cornea.5
Full thickness keratoplasty was the most common corneal transplantation technique over the last few decades, however, the popularity of selective lamellar transplantations of the affected layers of the cornea is increasing.
If the scar is relatively superficial, deep anterior lamellar keratoplasty (DALK) may be attempted.6 Otherwise, a traditional full thickness penetrating keratoplasty may be performed.7

Common types of corneal transplantations:

NameTechniqueIndicationComplications
Penetrating Keratoplasty (PKP)Removal of all layers of the host cornea with full thickness transplantation of the donor graft.Full-thickness scar, bullous keratopathy, keratoconus, graft failure.Graft rejection, graft failure, hemorrhage, infection, astigmatism, suture complications.
Deep Anterior Lamellar Keratoplasty (DALK)Diseased host epithelium and stroma removed. Transplant of donor cornea epithelium, Bowman’s membrane, and corneal stroma.Keratoconus, stromal scar, hereditary stromal dystrophies.Graft rejection, intraoperative Descemet membrane tear, astigmatism.
Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)Both endothelium and Descemet membrane are removed and replaced with the donor endothelium, Descemet membrane and stroma.Fuchs’ dystrophy, bullous keratopathy, graft failure.Graft detachment, graft failure, graft rejection.
Descemet membrane endothelial keratoplasty (DMEK)Both endothelium and Descemet membrane are removed and replaced with the donor endothelium and Descemet membrane.Fuchs’ dystrophy, bullous keratopathy, graft failure.Graft detachment, graft failure.8,9

Visual rehabilitation

In cases where vision cannot be rehabilitated (usually this happens when there is irreversible damage to other intraocular structures, or if the patient cannot undergo surgery to correct their condition), low vision therapy may be of significant help.

The goal of low vision rehabilitation is to train patients in strategies of coping with the diminished vision. Maintaining independence and improving the quality of life are the main objectives.

There are several options available with low vision programs; usually after assessment of vision, there are suggestions made for environmental modifications, introduction to assistive devices, and training.8
All state governments in the United States fund agencies to provide visual rehabilitation services. These agencies take care of most of the rehabilitative efforts, either directly or through subcontractors. Two examples of trusted low vision resources for patients are Helen Keller Services for the Blind and the Lighthouse Guild.9

Conclusion

Corneal scarring can be due to trauma, infections, ulceration, corneal dystrophies, or other diseases that may cause significant vision impairment. Management of the scarring depends on different factors including the histological location of the scar within the corneal tissue, the availability of corneal transplants, and the visual rehabilitation services.

References

  1. DelMonte DW, Kim T. Anatomy and physiology of the cornea. J Cataract Refract Surg. 2011;37(3):588-598. doi:10.1016/j.jcrs.2010.12.037
  2. Eghrari AO, Riazuddin SA, Gottsch JD. Overview of the Cornea: Structure, Function, and Development. Prog Mol Biol Transl Sci. 2015;134:7-23. doi:10.1016/bs.pmbts.2015.04.001
  3. Ahmed F, House RJ, Feldman BH. Corneal Abrasions and Corneal Foreign Bodies. Prim Care. 2015;42(3):363-375. doi:10.1016/j.pop.2015.05.004
  4. Bae SS, Chan CC. Superficial keratectomy: indications and outcomes. Can J Ophthalmol. 2018 Dec;53(6):553-559. doi: 10.1016/j.jcjo.2018.01.030. Epub 2018 Apr 4. PMID: 30502977.
  5. Singh R, Gupta N, Vanathi M, Tandon R. Corneal transplantation in the modern era. Indian J Med Res. 2019 Jul;150(1):7-22. doi: 10.4103/ijmr.IJMR_141_19. PMID: 31571625; PMCID: PMC6798607.
  6. Abdelaal AM, Alqassimi AH, Malak M, Hijazi HT, Hadrawi M, Khan MA. Indications of Keratoplasty and Outcomes of Deep Anterior Lamellar Keratoplasty Compared to Penetrating Keratoplasty. Cureus. 2021 Mar 11;13(3):e13825. doi: 10.7759/cureus.13825. PMID: 33859889; PMCID: PMC8040744.
  7. Liu S, Wong YL, Walkden A. Current Perspectives on Corneal Transplantation. Clin Ophthalmol. 2022 Mar 4;16:631-646. doi: 10.2147/OPTH.S289359. PMID: 35282172; PMCID: PMC8904759.
  8. Le R, Yucel N, Khattak S, Yucel YH, Prud'homme GJ, Gupta N. Current indications and surgical approaches to corneal transplants at the University of Toronto: A clinical-pathological study. Can J Ophthalmol. 2017 Feb;52(1):74-79. doi: 10.1016/j.jcjo.2016.07.005. Epub 2016 Sep 7. PMID: 28237153.
  9. Boynton GE, Woodward MA. Evolving Techniques in Corneal Transplantation. Curr Surg Rep. 2015 Feb 1;3(2):html. doi: 10.1007/s40137-014-0079-5. PMID: 26101726; PMCID: PMC4474142.
  10. Vision rehabilitation. AOA. https://www.aoa.org/practice/specialties/vision-rehabilitation?sso=y. Accessed July 19, 2022.
  11. E.P. Herlihy, P.N. Youssef, M.V. Netto, T.T. Shen; Management of a Severe Corneal Scar Using Lamellar Keratoplasty With a Standard Hansatome Microkeratome and a Frozen Globe . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4380.
Hayder Allkhenfr, MBBS, MPH
About Hayder Allkhenfr, MBBS, MPH

Dr. Hayder Allkhenfr received his undergraduate and MD degree at Alexandria University School of Medicine, Egypt. He completed 2 years of Ophthalmology training at Alex Eye Center before he moved to Salt Lake City, Utah for a postdoctoral research fellowship in neuro-ophthalmology at the Moran Eye Center, Utah during which, he obtained MPH with emphasis on Epidemiology and global health certificate at the University of Utah and led the TB/Refugee Health program at the Utah Department of Health from 2019-2022.

Hayder Allkhenfr, MBBS, MPH
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