Innovations in Dry Eye Symptom Relief: Long-Lasting Relief With Systane PRO

Dry eye disease is a common eye condition that affects millions worldwide.²Systane^® PRO Preservative-Free is the only triple-action preservative-free formula clinically proven to provide up to 12 hours of dry eye symptom relief.^1* It works to hydrate, restore, and protect dry eyes.¹

Systane^®’s Most Comprehensive, Long-Lasting Formula³

Systane^® PRO PF includes the demulcent propylene glycol to lubricate and soothe dry eyes⁴ and is supported by the HP-guar meshwork, lipids, and hyaluronic acid. Systane^® PRO PF is suitable for all types of dry eye.¹

All Systane^® Artificial Tears Use HP-GUAR

HP-guar and borate ions cross-link to form a gel-like structure in a pH-dependent mechanism^5,6†:

Mimics the tear film’s mucin layer and enhances its thickness^7,8††
Acts as a “bandage” to support healing of corneal epithelial cells^5,6‡‡
Lowers tear osmolarity^8§§

Recommend Systane^® PRO PF for Dry Eye Relief That Lasts up to 12 hours^1*

Takeaway 1

OTC artificial tears are a cornerstone of dry eye treatment. TFOS DEWS III (2025) emphasizes tailored, evidence-based management and formulations designed to stabilize the tear film and support ocular surface health.⁹

Takeaway 2

The unique formulation of Systane^® PRO PF includes a lubricant and several supporting polymers and lipids, for symptom relief in all types of dry eye.¹

Takeaway 3

In a clinical trial, Systane^® PRO PF provided up to 12 hours of dry eye symptom relief on Day 1, and improved tear film stability and symptom-related quality of life over 30 days.^1§§§

For eye care professionals managing patients with varying degrees of dry eye symptoms, Systane^® PRO Preservative-Free eye drops is for all types of dry eyes.¹

**Dr. Piuze and Dr Misener are paid consultants for Alcon.

DES, Dry Eye Symptom; HA, Hyaluronic Acid; IDEEL-SB, Impact of Dry Eye on Everyday Life – Symptom Bother; NIBUT, Noninvasive Breakup Time; PF, Preservative-Free.

*47% of patients experience meaningful symptom relief at 12 hours, N=153.

†In vitro data.

‡In vitro data; Based on Systane Complete formulation.

§In vitro data; Corneal epithelium model; P<0.001.

††Animal model; Based on Systane Ultra formulation.

‡‡In vitro data; Based on Systane Original formulation.

§§Based on Systane Ultra formulation.

***8.474 seconds vs. 7.215 seconds at baseline. The mean change from baseline on Day 30 did not meet the established threshold for clinically meaningful change of 2.5 seconds.

†††30.75 vs. 47.62 points at baseline. IDEEL-SB is a validated questionnaire that measures symptom bother, quality of life, and treatment satisfaction. Clinically meaningful improvement in IDEEL-SB defined as ≥12-point reduction from baseline.

‡‡‡ “outperform” refers to 2x greater moisture retention (compared to HA-only formulation)

§§§Dose = 1 drop 4 times a day; N=158

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